Modeling Plasmodium vivax: Relapses, treatment, seasonality, and G6PD deficiency
نویسندگان
چکیده
منابع مشابه
Modeling Plasmodium vivax: relapses, treatment, seasonality, and G6PD deficiency.
Plasmodium vivax (P. vivax) is one of the most important human malaria species that is geographically widely endemic and causes social and economic burden globally. However, its consequences have long been neglected and underestimated as it has been mistakenly considered a benign and inconsequential malaria species as compared to Plasmodium falciparum. One of the important differences between P...
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Most of the tens of millions of clinical attacks caused by Plasmodium vivax each year likely originate from dormant liver forms called hypnozoites. We do not systematically attack that reservoir because the only drug available, primaquine, is poorly suited to doing so. Primaquine was licenced for anti-relapse therapy in 1952 and became available despite threatening patients having an inborn def...
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BACKGROUND Plasmodium vivax infections contribute to a significant proportion of the malaria infections in many countries. Primaquine is the most widely used drug for treating the dormant liver stage. Different primaquine dosing regimens are in use. OBJECTIVES To compare primaquine regimens for preventing relapses in people with P. vivax malaria. SEARCH STRATEGY In 2006, we searched the Coc...
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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymatic disorder in humans and appears to be protective against falciparum severe malaria. Controversially, it is also thought that Plasmodium vivax has driven the recent selection of G6PD alleles. We use an experimental approach to determine whether G6PD-MahidolG487A variant, a widespread cause of severe G6PD deficiency i...
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ژورنال
عنوان ژورنال: Journal of Theoretical Biology
سال: 2013
ISSN: 0022-5193
DOI: 10.1016/j.jtbi.2012.08.024